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Fig. 5 | Annals of Clinical Microbiology and Antimicrobials

Fig. 5

From: Rapid Mycobacterium abscessus antimicrobial susceptibility testing based on antibiotic treatment response mapping via Raman Microspectroscopy

Fig. 5

Raman-barcode of cellular-response to stressors (RBCS) of MAB reveals distinct drug mode-of-action in CLA and LZD. (A) Dimensionality Reduction plots (UMAP) showing the overall distribution of NTM Raman spectrum data treated with CLA (top) and LZD (bottom). Each dot represents a Raman spectrum. Dots are colored based on the time of treatment. (B) UMAP plots as in (A) but cells are colored by clusters that were identified by a shared nearest neighbor (SNN) method. (C) Stacked barplots showing the percentage composition of clusters at each drug exposure timepoint. (D) Heatmaps showing Pearson’s correlation between CLA and LZD at each of the timepoints using data generated in (C)

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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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