Nanopore targeted sequencing-based diagnosis of central nervous system infections in HIV-infected patients

Yang, Xihong; Zhou, Shuilian; Chang, Ziwei; Xi, Xiaotong; Li, Jiahui; Miao, Mengjiao; Chen, Yaling; Chen, Wei; Zhang, Hongying; Ding, Ran; Hu, Zhiliang

doi:10.1186/s12941-024-00682-7

Fig. 3

From: Nanopore targeted sequencing-based diagnosis of central nervous system infections in HIV-infected patients

Associations of cryptococcal sequencing reads with CrAg and PCR. (A) The comparation of nanopore targeted sequencing (NTS) sequencing reads between groups of cerebrospinal fluid (CSF) cryptococcal antigen (CrAg) titer ≤1:640 and CSF CrAg titer > 1:640 of 27 patients with cryptococcal meningitis, and NTS sequencing reads of each case. (B) The relationship between NTS sequencing reads and cryptococcal PCR cycle threshold (Ct) value of 28 patients. Of 7 cases with negative PCR results, the Ct value was considered as maximum thermal cycles of 40. In both A and B, when NTS sequencing reads was 0, it was adjusted to 0.2 for the purpose of analysis

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Fig. 3

Annals of Clinical Microbiology and Antimicrobials

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