Fig. 5

Time-kill kinetics of three antimicrobial drug combinations against M. avium complex. Two strains, M. intracellulare #5151 (A to C) and M. avium subsp. hominissuis #460 (D to F), were used in this analysis. The combinations included standard regimen drugs (CRE- containing clarithromycin at 2 µg/ml, rifampicin at 1 µg/ml, and ethambutol at 2 µg/ml), CB combination (containing clarithromycin at 2 µg/ml and bedaquiline at 0.25 µg/ml), and CP combination (containing clarithromycin at 2 µg/ml and prothionamide at 32 µg/ml). Error bars represent standard deviation, and statistical significance was analyzed using the ANOVA (* p < 0.05; ** p < 0.01; *** p < 0.001)