Table 2 Univariate analysis: association between the microorganism and other independent variables with composite outcome (death or recurrence)
Variables | Events | Persons-day | Rate per 1000 (95% CI) | Rate ratio (95% CI)* | p-value†|
|---|---|---|---|---|---|
Microorganism | |||||
 K. pneumoniae | 58 | 7196 | 8.06 (6.23–10.43) | Model 1‡: 1.00 Model 2§: 0.86 (0.48–1.50) | 0.379 |
 E. cloacae | 15 | 1555 | 9.65 (5.82–16.00) | Model 1‡: 1.18 (0.67–2.10) Model 2§: 1.00 | |
 K. aerogenes | 2 | 609 | 3.28 (0.82–13.13) | Model 1‡: 0.42 (0.10–1.71) Model 2§: 0.35 (0.08–1.55) | |
Sex | |||||
 Female | 33 | 3285 | 10.05 (7.14–14.13) | 1.00 | 0.110 |
 Male | 41 | 6028 | 6.80 (5.01–9.24) | 0.69 (0.43–1.09) | |
Age | |||||
 18–59 | 12 | 2425 | 4.95 (2.81–8.71) | 1.00 | 0.039 |
 60–69 | 16 | 2657 | 6.02 (3.69–9.83) | 1.17 (0.55–2.49) | |
 70–79 | 29 | 2609 | 11.12 (7.72–16.00) | 2.21 (1.12–4.36) | |
 ≥ 80 | 18 | 1669 | 10.78 (6.79–17.12) | 2.14 (1.02–4.46) | |
Charlson index | |||||
 < 5 | 19 | 5149 | 3.69 (2.35–5.79) | 1.00 | 0.001 |
 ≥ 5 | 56 | 4211 | 13.30 (10.23–17.28) | 3.56 (2.11–6.01) | |
Department responsible | |||||
 Medical | 45 | 5132 | 8.77 (6.55–11.74) | 1.00 | 0.198 |
 Surgery | 10 | 2145 | 4.66 (2.51–8.66) | 0.53 (0.27–1.06) | |
 ICU | 13 | 1168 | 11.13 (6.46–19.17) | 1.22 (0.65–2.30) | |
 Other | 4 | 717 | 5.58 (2.09–14.86) | 0.66 (0.24–1.87) | |
Setting of BSI acquisition | |||||
 Community | 20 | 1994 | 10.03 (6.47–15.55) | 1.00 | 0.258 |
 Nosocomial | 41 | 4947 | 8.29 (6.10–11.26) | 0.79 (0.46–1.37) | |
 HAI | 14 | 2419 | 5.79 (3.43–9.77) | 0.56 (0.28–1.12) | |
BSI source | |||||
 Abdominal | 19 | 2245 | 8.46 (5.40–13.27) | 1.00 | 0.598 |
 Catheter | 5 | 1156 | 4.33 (1.80–10.39) | 0.51 (0.19–1.38) | |
 Respiratory | 7 | 617 | 11.35 (5.41–23.80) | 1.35 (0.56–3.24) | |
 Urinary | 27 | 3401 | 7.94 (5.44–11.58) | 0.93 (0.51–1.68) | |
 Other | 3 | 226 | 13.27 (4.28–41.16) | 1.60 (0.47–5.47) | |
 Unknown | 13 | 1711 | 7.60 (4.41–13.09) | 0.87 (0.43–1.77) | |
Pitt score | |||||
 < 4 | 55 | 8647 | 6.36 (4.88–8.28) | 1.00 | 0.001 |
 ≥ 4 | 20 | 713 | 28.06 (18.10–43.48) | 4.47 (2.63–7.59) | |
Severe sepsis | |||||
 No | 51 | 7695 | 6.63 (5.04–8.72) | 1.00 | 0.002 |
 Yes | 24 | 1665 | 14.41 (9.66–21.51) | 2.16 (1.32–3.54) | |
Septic shock | |||||
 No | 53 | 8328 | 6.36 (4.86–8.33) | 1.00 | 0.001 |
 Yes | 22 | 1032 | 21.32 (14.04–32.38) | 3.45 (2.08–5.74) | |
ESBL production | |||||
 No | 37 | 5182 | 7.14 (5.17–9.85) | 1.00 | 0.616 |
 Yes | 15 | 1737 | 8.64 (5.21–14.32) | 1.17 (0.63–2.17) | |
Carbapenemase production | |||||
 No | 40 | 5501 | 7.27 (5.33–9.91) | 1.00 | 0.894 |
 Yes | 5 | 704 | 7.10 (2.96–17.06) | 1.07 (0.41–2.81) | |
Active empiric antibiotic | |||||
 No | 12 | 1523 | 7.88 (4.48–13.87) | 1.00 | 0.863 |
 Yes | 50 | 6848 | 7.30 (5.53–9.63) | 0.94 (0.49–1.81) | |
Time to start ATB | |||||
 Before | 16 | 1591 | 10.06 (6.16–16.42) | 1.00 | 0.473 |
 Same day | 38 | 5747 | 6.61 (4.81–9.09) | 0.69 (0.38–1.25) | |
 ≥ 1 days after | 9 | 1248 | 7.21 (3.75–13.86) | 0.74 (0.32–1.70) | |