Fig. 1

Clinical manifestation: A well-defined dark red plaque on the right leg with scales and crusts on the surface(a). The patient had previously been treated with oral itraconazole and terbinafine 3 months and proved subtherapeutic effect(b for 1 month and c for 3 months). Imiquimod improved the lesions was observed after 1, 2, 3, 5, 10 months (d, e and f, g respectively)