Table 2 Minimum inhibitory concentrations of 22 antibiotics against BSI-Kpn
From: Genomic and immunocyte characterisation of bloodstream infection caused by Klebsiella pneumoniae
Antibiotics | CRKP | ESBL-Kpn | S-Kpn | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
MIC range (mg/L) | MIC90 (mg/L) | S (N/%) | R (N/%) | MIC range (mg/L) | MIC90 (mg/L) | S (N/%) | R (N/%) | MIC range (mg/L) | MIC90 (mg/L) | S (N/%) | R (N/%) | |
Aztreonam | 0.125– > 64 | 64 | 3 (3.7) | 78 (96.3) | 0.125– > 64 | 64 | 6 (20.0) | 24 (80.0) | 0.03–32 | 1 | 59 (95.2) | 2 (3.2) |
Moxalactam | 0.25– > 128 | 128 | 2 (2.5) | 76 (93.8) | 0.06–128 | 8 | 29 (96.7) | 1 (3.3) | 0.125–128 | 2 | 60 (96.8) | 1 (1.6) |
Cefoxitin | 2– > 128 | 128 | 4 (4.9) | 77 (95.1) | 4–128 | 32 | 18 (60.0) | 6 (20.0) | 2–64 | 32 | 52 (83.9) | 7 (11.3) |
Cefuroxime | 2– > 128 | 128 | 2 (2.5) | 79 (97.5) | 4– > 128 | 128 | 1 (3.3) | 27 (90.0) | 1–128 | 32 | 45 (72.6) | 10 (16.1) |
Cefazolin | 0.5– > 128 | 128 | 2 (2.5) | 79 (97.5) | 2– > 128 | 128 | 1 (3.3) | 29 (96.7) | 0.25–128 | 128 | 41 (66.1) | 11 (17.7) |
Ceftazidime | 0.12– > 64 | 64 | 2 (2.5) | 79 (97.5) | 1– > 64 | 64 | 8 (26.7) | 19 (63.3) | 0.12–32 | 2 | 58 (93.5) | 3 (4.8) |
Ceftriaxone | 0.125– > 64 | 64 | 2 (2.5) | 79 (97.5) | 0.25– > 64 | 64 | 3 (10.0) | 27 (90.0) | 0.03–32 | 2 | 56 (90.3) | 3 (4.8) |
Cefepime | 0.06– > 64 | 64 | 4 (4.9) | 77 (95.1) | 0.125–64 | 32 | 6 (20.0) | 20 (66.7) | 0.015–16 | 0.5 | 59 (95.2) | 2 (3.2) |
AMC | 16– > 128 | 128 | 2 (2.5) | 38 (46.9) | 4–64 | 32 | 5 (16.7) | 7 (23.3) | 1–64 | 16 | 55 (88.7) | 2 (3.2) |
TZP | 4– > 128 | 128 | 2 (2.5) | 52 (64.2) | 2– > 128 | 128 | 11 (36.7) | 8 (26.7) | 0.25–128 | 32 | 55 (88.7) | 3 (4.8) |
CSL | 0.25–128 | 128 | 3 (3.7) | 45 (55.6) | 4–128 | 128 | 12 (40.0) | 10 (33.3) | 0.03–32 | 8 | 61 (98.4) | 1 (1.6) |
Ertapenem | 0.015– > 32 | 32 | 3 (3.7) | 78 (96.3) | 0.004–32 | 0.5 | 27 (90.0) | 3 (10.0) | 0.004–0.5 | 0.125 | 62 (100.0) | 0 (0.0) |
Imipenem | 0.125– > 32 | 32 | 3 (3.7) | 78 (96.3) | 0.03–32 | 1 | 30 (100.0) | 0 (0.0) | 0.03–1 | 1 | 62 (100.0) | 0 (0.0) |
Meropenem | 0.015– > 32 | 32 | 3 (3.7) | 78 (96.3) | 0.008–32 | 0.25 | 30 (100.0) | 0 (0.0) | 0.008–32 | 0.06 | 62 (100.0) | 0 (0.0) |
Gentamicin | 0.5–> 128 | 128 | 12 (14.8) | 60 (74.1) | 0.25–128 | 128 | 16 (53.3) | 12 (40.0) | 0.25–128 | 8 | 55 (88.7) | 4 (6.5) |
Amikacin | 1– > 128 | 128 | 18 (22.2) | 30 (37.0) | 1–128 | 16 | 28 (93.3) | 2 (6.7) | 0.25–8 | 8 | 62 (100.0) | 0 (0.0) |
Levofloxacin | 0.06– > 32 | 32 | 2 (2.5) | 78 (96.3) | 0.25– > 32 | 32 | 4 (13.3) | 16 (53.3) | 0.03–32 | 16 | 41 (66.1) | 4 (6.5) |
Ciprofloxacin | 0.015– > 32 | 32 | 2 (2.5) | 79 (97.5) | 1–128 | 32 | 3 (10.0) | 26 (86.7) | 0.004–32 | 4 | 46 (74.2) | 13 (21.0) |
Fosfomycin | 2–256 | 256 | 55 (67.9) | 19 (23.5) | 0.5–64 | 16 | 30 (100.0) | 0 (0.0) | 0.25–256 | 16 | 59 (95.2) | 1 (1.6) |
SXT | 0.015– > 8 | 8 | 39 (48.1) | 42 (51.9) | 0.015– > 8 | 8 | 5 (16.7) | 25 (83.3) | 0.015–8 | 8 | 54 (87.1) | 8 (12.9) |
Tigecycline | 0.125–4 | 2 | 77 (95.1) | 0 (0.0) | 0.125–4 | 2 | 29 (96.7) | 0 (0.0) | 0.125–2 | 1 | 62 (100.0) | 0 (0.0) |
Polymyxin B | 0.25–32 | 2 | 74 (91.4) | 7 (8.6) | 0.5–8 | 2 | 29 (96.7) | 1 (3.3) | 0.5–16 | 2 | 59 (95.2) | 3 (4.8) |