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Table 3 Summary of antimycobacterial therapy over more than 10 years of follow-up

From: Long-term successfull management of recurrent episodes of nontuberculous mycobacterial infection in an apparently healthy Chinese woman

Date

Event

Antimycobacterial therapy

Duration

2011

Disseminated Mycobacterium szulgai

Mycobacterium isolation

INH toxicity

Suspected AZM intolerance

INH, RIF, EMB and AZM

RIF, EMB and AZM

RIF, EMB and MXF

16 Months

11 Months

4 Months

1 Months

2014

Disseminated MAC

Mycobacterium isolation

Antibiogram available

Vertebral lesions worsening

Vertebral lesions improvement

Simplified treatment

RIF, EMB and MXF

RIF, EMB and AZM

RIF, EMB, AZM, AMK and CLO

RIF, EMB, AZM and CLO

RIF, EMB, AZM

44 Months

2 Months

5 Months

5 Months

3 Months

29 Months

2018

Suspected relapse/reinfection of dNTM

Thoracic lymphadenopathies/pneumonia

RIF, EMB and AZM

7 Months

7 Months

2020

Suspected relapse/reinfection of dNTM

Patient’s decision

Lymphadenopathies/splenic and skeletal lesions recurrence

Lymphadenopathies/splenic and skeletal lesions improvement

RIF, EMB, AZM (discontinuous)

RIF, EMB, AZM, AMK and CLO

RIF, EMB, AZM and CLO

RIF, EMB, AZM

40 Months

2 Weeks

5 Months

23 Months

10 Months (ongoing)

  1. Abbreviations INH: isoniazid; RIF: rifampicin; EMB: ethambutol; AZM: azithromycin; MXF: moxifloxacin; AMK: amikacin; CLO: clofazimine; MAC: mycobacterium avium complex; dNTM: disseminated nontuberculous mycobacteria
  2. Toxicities. peripheral polyneuropathy (INH); sensorineural hearing loss (AMK, AZM); skin hyperpigmentation (CLO); suspected intolerance (AZM, MXF)