Fig. 4

Heatmap of significantly differentially expressed proteins. The results of hierarchical clustering were represented as a tree heat map. The horizontal axis represents the samples with different colors to indicate sample grouping information. The vertical axis represents differentially expressed proteins, with significant changes denoted by vertical coordinates. Significantly differentially expressed proteins across samples were normalized using the Z-score method and are presented in the heatmap with no colors. The red color indicates significantly upregulated proteins, the green color represents significantly downregulated proteins, and the grey color represents no protein quantification information