Table 3 Cytokines profiles and laboratory testing associated with 30-day mortality
From: Dynamic cytokine profiles of bloodstream infection caused by Klebsiella pneumoniae in China
Indexes | Day1 | Day3 | Day7 | Day14 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Survivors | Death | P-value | Survivors | Death | P-value | Survivors | Death | P-value | Survivors | Death | P-value | |
Arginase (ng/mL) | 147.0 (41.0-330.9) | 250.5 (15.4–450.0) | 0.987 | 71.0 (24.9–287.0) | 152.8 (24.7-308.4) | 0.731 | 101.8 (39.8-250.8) | 97.1 (33.6-459.4) | 0.851 | 98.5 (32.2-220.1) | 73.6 (29.3-332.1) | 0.695 |
INF-γ (pg/mL) | 0.0 (0-39.5) | 0 (0-103.5) | 0.528 | 0 (0-1.7) | 0 (0-7.1) | 0.806 | 0 (0–0) | 0 (0–0) | 0.622 | 0 (0–0) | 0 (0–0) | 0.281 |
TNF-α (pg/mL) | 3.1 (0-12.1) | 5.9 (0.6–51.0) | 0.335 | 0 (0-8.3) | 2.4 (0-7.6) | 0.471 | 0 (0-9.6) | 3.7 (0-16.2) | 0.257 | 0 (0-12.8) | 2.9 (0-9.8) | 0.944 |
IL-1β (pg/mL) | 0 (0-13.7) | 0.1 (0-22.4) | 0.832 | 0 (0-6.9) | 0 (0–0) | 0.261 | 0 (0-9.3) | 0 (0-23.9) | 0.941 | 0 (0-8.2) | 0 (0-11.6) | 0.794 |
IL-4 (pg/mL) | 0 (0-3.9) | 0 (0-7.4) | 0.381 | 0 (0–4.0) | 3.3 (0-13.1) | 0.201 | 0 (0-7.8) | 0 (0-20.3) | 0.817 | 0 (0-5.6) | 1 (0-19.8) | 0.488 |
IL-6 (pg/mL) | 116.7 (43.5-680.7) | 160.3 (79.5-2499.7) | 0.273 | 69.6 (20.6-287.8) | 409.7 (216.9-824.3) | 0.001 | 84.9 (24.6-185.7) | 103.6 (47.4-323.9) | 0.160 | 42.7 (19.1-109.9) | 193.8 (102.5-317.2) | 0.000 |
IL-10 (pg/mL) | 12.8 (2.8–54.1) | 23.2 (11.6–66.3) | 0.150 | 5.1 (2.0-16.9) | 27.7 (9.6–66.5) | 0.003 | 4.3 (1.6–10.6) | 25.2 (12.0-71.7) | 0.001 | 3.9 (1.5–8.3) | 18.3 (9.8-116.8) | 0.000 |
IL-12 (p70) (pg/mL) | 0.8 (0-3.8) | 0.5 (0–5.0) | 0.790 | 0.7 (0-2.7) | 0.8 (0-6.3) | 0.633 | 0.5 (0-2.5) | 2.1 (0.2–11.2) | 0.060 | 0.7 (0-2.3) | 0.2 (0-4.1) | 0.973 |
IL-23 (pg/mL) | 1.9 (0-9.3) | 0.8 (0-3.9) | 0.579 | 0.9 (0-8.6) | 1.9 (0-3.7) | 0.879 | 1.0 (0-11.1) | 1.3 (0-7.2) | 0.846 | 1.3 (0-5.7) | 0.7 (0-2.7) | 0.684 |
WBC (*10E9/L) | 8.5 (5.3–14) | 10.3 (1.5–16.5) | 0.967 | 7.4 (4.8–10.8) | 10.4 (2.8–12.0) | 0.844 | 7.0 (4.8–10.0) | 7.5 (3.1–15.6) | 0.719 | |||
N (%) | 88.3 (82.0-92.6) | 91.8 (86.1–96.2) | 0.139 | 82.1 (72.9–86.7) | 84.6 (54.3–92.7) | 0.545 | 78.9 (68.0-85.1) | 88.4 (60.8–90.7) | 0.185 | |||
Hb (g/L) | 94.0 (72.0-117.0) | 80.5 (65.3–89.3) | 0.023 | 82.0 (70.0-104.0) | 65.5 (63.3–70.8) | 0.001 | 78.0 (70.0–99.0) | 66.0 (52.5–76.3) | 0.004 | |||
PLT (*10E9/L) | 103.0 (53.0-170.0) | 55.0 (11.8-238.5) | 0.452 | 117.0 (50.0-224.0) | 65.0 (38.8-205.5) | 0.208 | 211.0 (107.0-278.0) | 58.5 (11.5-199.5) | 0.004 | |||
CRP (mg/L) | 68.0 (27.9-131.4) | 107.3 (42.8-171.7) | 0.423 | 38.4 (12.9–68.8) | 90.5 (63.3–111.0) | 0.010 | 22.6 (6.4–47.3) | 81.5 (48.1-131.2) | 0.002 | |||
PCT (ng/mL) | 1.7 (0.6–11.5) | 1.2 (0.6–9.6) | 0.744 | 0.4 (0.2-1.0) | 0.8 (0.6–1.4) | 0.089 | 0.3 (0.2–0.6) | 0.9 (0.4–1.9) | 0.012 | |||
Alb (g/L) | 32.9 (27.6–36.8) | 31.2 (29.1–36.5) | 0.624 | 33.1 (31.0-37.2) | 34.2 (29.0-37.5) | 0.864 | 35.2 (32.7–38.1) | 34.1 (29.5–36.2) | 0.236 | |||
ALT (U/L) | 29.0 (15.0–63.0) | 45.5 (26.0-110.5) | 0.082 | 28.0 (18.0–44.0) | 32.0 (21.3–54.8) | 0.368 | 26.0 (17.0–41.0) | 20.5 (13.8–34.0) | 0.452 | |||
AST (U/L) | 30.0 (16.0–60.0) | 47.0 (25.3–92.0) | 0.098 | 24.0 (16.0–42.0) | 40.0 (28.0–63.0) | 0.042 | 23.0 (16.0–38.0) | 25.5 (18.3–71.0) | 0.310 | |||
CHE (U/L) | 3154 (2373.0-4523.0) | 2251.5 (1285.0-2572.0) | 0.007 | 3094.0 (2137.0-4522.0) | 2546.5 (1157.3-3025.8) | 0.024 | 3241.0 (2174.0-4346.0) | 1330.0 (1157.0-2544.8) | 0.001 | |||
Tbil (µmol/L) | 20.1 (9.8–35.6) | 41.3 (16.5-186.4) | 0.048 | 16.3 (11.2–30.7) | 62.2 (26.1–80.2) | 0.001 | 14.5 (9.4–30.3) | 69.8 (21.5–130.0) | 0.001 | |||
Cr (µmol/L) | 77.0 (54.0–99.0) | 90.0 (46.8–154.0) | 0.967 | 67.0 (47.0–93.0) | 63.5 (39.8-121.5) | 0.864 | 64.0 (48.0–92.0) | 60.5 (39.0-148.8) | 0.665 | |||
INR | 1.1 (1.1–1.2) | 1.3 (1.1–1.4) | 0.047 | 1.2 (1.1–1.3) | 1.3 (1.1–1.6) | 0.145 | 1.2 (1.1–1.3) | 1.4 (1.2–1.7) | 0.006 | |||