Fig. 1

Strain isolation and antibiotic administration. (A) Clinical data for 10 patients in chronological order. ○: First non-blaKPC−2-carrying CRKP strains for further analysis. (B) Medical history and antibiotic stewardship of Patient 10 and the corresponding strains. (C) Phylogenetic tree and heat map of demographic data of 10 patients, and the molecular characteristics and β-lactamase genes of their corresponding CRKP strains. Notes: CRKP: Carbapenem-resistant Klebsiella pneumoniae