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Fig. 4 | Annals of Clinical Microbiology and Antimicrobials

Fig. 4

From: Ceftazidime-avibactam treatment dilemma of blaKPC−2-containing Klebsiella pneumoniae due to the development of co-existence of mixed strains carrying blaKPC−2 or blaKPC−33 in lung transplant recipients

Fig. 4

In vitro induction experiment. (A) Procedure: LB broth with different CAZ/AVI concentrations (36/5 mg/L, 48/6.7 mg/L, 60/8.3 mg/L, and 72/10 mg/L, respectively, the same below) divided into two groups. After overnight induction, suspensions were measured for absorbance and sequenced. (B) Results: (1) OD600 of KP40034-mix with CAZ/AVI at differet concentrations: Significant decrease in strains as CAZ/AVI concentration exceeds MIC of mix strains. (2) OD600 of KP40034-2 S with CAZ/AVI at differet concentrations: Strain count remains low due to susceptibility to CAZ/AVI. (3) Proportion of blaKPC−33 in KP40034-mix at different CAZ/AVI concentrations: Increases with induction time; insufficient CAZ/AVI doses decrease blaKPC−2 but increase blaKPC−33. (4) AST of KP40034-mix: Susceptibility to CAZ/AVI increases over time. Notes: AST: antimicrobial susceptibility testing

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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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