Comparing the diagnostic value of targeted with metagenomic next-generation sequencing in immunocompromised patients with lower respiratory tract infection

Table 3 Diagnostic performance of NGS in difference groups compared with composite reference standard

Ptients characteristics		tNGS				mNGS
		Positive	Negative	Sensitivity(%)	Specificity(%)	Positive	Negative	Sensitivity(%)	Specificity(%)
immunocompromised	Positive by composite reference standard	50	3	94.33	0	49	4	92.45	100
	Negative by composite reference standard	1	0			0	1
immunocompetent	Positive by composite reference standard	26	5	83.87	66.67	25	6	80.65	66.67
	Negative by composite reference standard	1	2			1	2

Abbreviations tNGS: Targeted Next-generation sequencing; mNGS: Metagenomic next-generation sequencing; PPV: Positive predictive value; NPV: Negative predictive value

ISSN: 1476-0711