Table 2 Diagnostic efficiency of the five tests for intracranial tuberculosis
From: Nanopore-targeted sequencing (NTS) for intracranial tuberculosis: a promising and reliable approach
Test | Sensitivity(%,95%CI) | Specificity(%,95%CI) | PPV(%,95%CI) | NPV(%,95%CI) | AUC(95%CI) |
|---|---|---|---|---|---|
NTS | 60.0(49.7–69.5) | 95.5(75.1–99.8) | 98.4(90.0-99.9) | 34.4 (23.0-47.8) | 0.78(0.71–0.84) |
Xpert | 5.0(1.9–11.8) | 95.5(75.1–99.8) | 83.3(36.5–99.1) | 18.1(11.8–26.6) | 0.50(0.45–0.55) |
MTB culture | 2.0(0.3–7.7) | 100.0(81.5–100.0) | 100.0(19.8–100.0) | 18.3(12.1–26.7) | 0.51(0.50–0.52) |
PCR | 1.0(0.1–6.2) | 100.0(81.5–100.0) | 100.0(5.5–100) | 18.2(12.0-26.5) | 0.51(0.50–0.51) |
AFB smear | 0.0(0.0-4.6) | 100.0(81.5–100.0) | / | 18.0(11.9–26.3) | 0.50(0.50–0.50) |