Usefulness of sonication in the microbiological diagnosis of cardiovascular implantable electronic device infections: systematic review, meta-analysis and meta-regression

Martín-Gutiérrez, Guillermo; Martín-Pérez, Carlos; Ortiz-de la Rosa, José Manuel; Gutiérrez-Carretero, Encarnación; de Alarcón, Arístides; Lepe, José Antonio

doi:10.1186/s12941-024-00753-9

Annals of Clinical Microbiology and Antimicrobials

Table 2 Summary of study characteristics

From: Usefulness of sonication in the microbiological diagnosis of cardiovascular implantable electronic device infections: systematic review, meta-analysis and meta-regression

Author and Year	Culture type	Culture criteria	TP	FP	TN	FN	Sensitivity	Sensitivity CI 95%	Specificity	Specificity CI 95%
Nagpal 2015	Sonicated	Any growth	19	2	40	16	0.543	0.366–0.712	0.952	0.838–0.994
	Sonicated	Threshold of 2 CFU/ml	26	17	25	9	0.743	0.567–0.875	0.595	0.433–0.744
	Tissue	Any growth	3	2	40	32	0.086	0.018–0.231	0.952	0.838–0.994
	Tissue	Threshold of 2 CFU/ml	16	17	25	19	0.457	0.288–0.634	0.595	0.433–0.744
	Swab	Any growth	10	2	40	25	0.286	0.146–0.463	0.952	0.838–0.994
	Swab	Threshold of 2 CFU/ml	25	14	28	10	0.714	0.537–0.854	0.667	0.505–0.804
El-Ashry 2021	Sonicated	Threshold of 20 CFU/ml	18	12	21	1	0.947	0.740–0.999	0.636	0.451–0.796
	Tissue		10	5	28	9	0.526	0.289–0.756	0.848	0.681–0.949
	Swab		6	3	30	13	0.316	0.126–0.566	0.909	0.757–0.981
Inacio 2015	Sonicated	Any growth	10	35	33	3	0.769	0.462–0.950	0.485	0.362–0.610
Inacio 2015	Tissue	Threshold of 5 CFU/ml	4	0	16	11	0.267	0.078–0.551	1.000	0.713–1000
Rohacek 2010	Sonicated	Any growth	6	44	71	0	1.000	0.421–1000	0.617	0.522–0.706
Rohacek 2010	Swab	Any growth	4	30	82	2	0.667	0.223–0.957	0.732	0.640–0.811
Oliva 2013	Sonicated	Threshold of 2 CFU/ml	18	8	12	2	0.900	0.683–0.988	0.600	0.361–0.809
Oliva 2013	Tissue	Threshold of 2 CFU/ml	16	4	16	4	0.800	0.563–0.943	0.800	0.563–0.943
Mason 2011	Sonicated	Any growth	15	11	55	1	0.938	0.698–0.998	0.833	0.721–0.914
	Tissue		13	8	58	3	0.812	0.544–0.960	0.879	0.775–0.946
	Swab		11	2	64	5	0.688	0.413–0.890	0.970	0.895–0.996
Esquer 2021	Sonicated	Threshold of 2 CFU/ml	178	1	43	100	0.640	0.581–0.697	0.977	0.880–0.999
Nguyen 2015	Sonicated	Any growth	28	4	39	8	0.778	0.608–0.899	0.907	0.779–0.974
Chua 2005	Tissue	Any growth	24	10	26	11	0.686	0.507–0.831	0.722	0.548–0.858
Chua 2005	Swab	Any growth	11	8	28	24	0.314	0.169–0.493	0.778	0.608–0.899

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ISSN: 1476-0711

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