Fig. 6

Graphs obtained from comparative analysis data between metabolites of healthy (H), adenomatous polyp (AP), and cancer tumor (CT) groups. The OPLS-DA (Orthogonal partial least squares-discriminant analysis) score plots (6A-6C), OPLS-DA model validation with permutation tests (2000 permutations) and cross-validation (6D-6F), VIP (variable importance in projection) plots (6G-6I), and significant analysis of metabolites (SAM) (6J-6L). The green points represent metabolites that were significantly different between H vs. CT (6J), H vs. AP (6K), and AP vs. CT (6L). The solid diagonal line represents “observed = expected”. The more the variable diverges from the solid line the more likely it is to be significant