Fig. 11

Representative photomicrographs exhibited H & E-stained skin Sect. (8 days) (scale bar, 100 μm, × 100). (A) Microscopic photographs of skin tissues obtained from control and treated groups after 8 days. The untreated group shows intense inflammatory cells infiltration and marked edema. PSK- and vancomycin- treated groups (2 hpi) demonstrate re-epithelialization, inflammatory cells infiltration and granulation tissue formation. The delayed treatment with both agents (2dpi) showing re-epithelialization and good granulation tissue formation. Black arrows indicate re-epithelialization; red arrows indicate inflammatory cells; blue arrow indicate granulation tissue. The statistical analysis of the histopathological scores of necrosis (B), inflammatory cells infiltration (C). The data expressed as the median and interquartile range (p25-p75). Statistics were carried out by Kruskal Wallis test followed by Dunn test. (D) The antibacterial activity of either PSK or vancomycin after 2 hpi or dpi. *, p < 0.05; **, p < 0.01; ***, p < 0.001