Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications

Yaslianifard, Somayeh; Sameni, Fatemeh; Kazemi, Kimia; Atefpour, Yousef; Hajikhani, Bahareh; Baradaran Bagheri, Ali; Yazdani, Shahrooz; Dadashi, Masoud

doi:10.1186/s12941-025-00788-6

Annals of Clinical Microbiology and Antimicrobials

Table 1 Characteristics of the included studies

From: Beyond the gut: a comprehensive meta-analysis on Helicobacter pylori infection and cardiovascular complications

First author	Published time	Country	Number of patients	Number of H. pylori isolates	Mean age	Male	Female
Tano [22]	2000	Italy	206	89	58 ± 7	196	10
Garcia [23]	2001	Spain	100	75	NR	75	25
Pinar [24]	2004	Turkey	33	14	NR	NR	NR
Sheehan [25]	2005	Ireland	227	139	59.4	162	65
Jeong [26]	2003	Korea	272	171	59.1 ± 10.4	208	64
Ziver [27]	2010	Turkey	96	67	62.94	76	20
Grub [28]	2012	Norway	119	51	NR	76	43
Lanza [29]	2004	Italy	104	53	NR	53	51
Preusch [30]	2004	Germany	190	104	59.5 ± 11.7	125	65
Sawayama1 [31]	2005	Japan	62	48	71.5 ± 11.3	40	22
Kaehler [32]	2006	Germany	205	100	NR	168	37
Bai [33]	2017	Pakistan	109	82	50.93 ± 8.13	55	54
Davoudi [34]	2011	Iran	69	40	60.5 ± 1.05	53	16
Masoud [35]	2005	Iran	91	59	64.3 ± 10	48	43
Heuschmann [36]	2001	Germany	145	67	74.6	68	77
Fan [37]	2021	China	76	31	70.1	50	26
Palm [38]	2016	Germany	470	182	NR	282	188
Vijayvergiya [39]	2006	India	90	38	NR	NR	NR
Vafaeimanesh [40]	2014	Iran	62	45	NR	36	26
Ponzetto [41]	2002	Italy	80	64	56.7	58	22
Shmuely [42]	2014	Israel	173	110	68.5	124	49
Gabrielli [43]	2004	Italy	105	75	68 ± 8	49	56
Bloemenkamp [44]	2002	Netherlands	228	91	48.0 ± 7.0	0	228
Yamamoto [45]	2012	Japan	64	33	72.2 ± 7.5	38	26
Yang [46]	2011	China	150	101	66 ± 9	105	45
Sawayama2 [47]	2008	japan	69	55	63.38 ± 10.28	33	36
Padmavati [48]	2012	India	110	69	NR	NR	NR
Nikolopoulou [49]	2008	Greece	288	146	62.4 ± 0.61	258	130
Vahdat [50]	2007	Iran	222	149	NR	NR	NR
Niccoli1 [51]	2010	Italy	40	24	63.3 ± 11	33	7
Witherell [52]	2003	USA	121	84	55	68	53
Figura1 [53]	2014	Italy	103	41	65 ± 8	70	33
Hoffmeister [54]	2001	Germany	238	90	NR	NR	NR
Schiele [55]	2001	France	180	61	56	158	22
Li [56]	2021	China	88	54	NR	28	60
Niccoli2 [57]	2017	Italy	181	108	64 ± 13	155	26
Badran [58]	2007	Egypt	185	113	NR	111	74
Pietroiusti [59]	2002	Italy	199	137	NR	119	80
Dore [60]	2003	Italy	32	23	69 ± 8.3	27	5
Kilic [61]	2006	Turkey	29	14	37.6	23	7
Iriz [62]	2008	Turkey	42	11	57.3 ± 11.4	33	9
Ameriso [63]	2001	Argentina	38	20	67 ± 9	29	9
Kowalski1 [64]	2002	Germany	46	22	62.7 ± 9.17	37	9
Assanelli [65]	2004	Italy	48	29	35.4	43	5
Schumacher [66]	2002	Norway	193	86	55	158	35
Yusuf [67]	2002	England	40	19	81	NR	NR
Choussat [68]	2000	France	79	33	NR	50	29
Stone [69]	2002	England	310	157	NR	NR	NR
Elizalde [70]	2004	Spain	92	49	NR	NR	NR
Oijen [71]	2007	Netherlands	376	186	64.7	227	149
Horne [72]	2002	USA	415	216	62 ± 11	332	83
Kahan [73]	2000	Sweden	99	67	66.4	76	23
Kowalski2 [74]	2001	Germany	96	67	NR	NR	NR
Aceti [75]	2004	Italy	40	28	60.67 ± 12.42	34	6
Aldhalmi [76]	2020	Iraq	100	56	NR	50	50
Vcev [77]	2007	Croatia	90	71	49.2	61	30
Osawa [78]	2001	Japan	206	137	59.8 ± 0.5	175	31
Fallah [79]	2016	Iran	96	77	51.32 ± 2.61	68	28
Jukic [80]	2017	Croatia	150	87	62.61 ± 10.23	109	41
Park [81]	2006	Korea	125	100	66.74 ± 7.69	63	62
Grau [82]	2001	Germany	109	57	60 ± 14.7	73	36
Moayyedi [83]	2003	England	467	274	70.5	239	228
Lazaraki [84]	2008	Greece	102	57	75.44 ± 19	48	54
Sarraf [85]	2001	Iran	103	49	55 ± 8.0	80	23
Kanbay [86]	2005	Turkey	151	91	48.1	93	58
Tabata [87]	2016	Japan	253	112	NR	NR	NR
Figura2 [88]	2002	Italy	63	50	65	NR	NR
Galante [89]	2000	Italy	63	32	64.1 ± 9.34	47	16
Murray [90]	2000	England	259	183	NR	74	185
Rogha [91]	2012	Iran	62	30	62.4 ± 9.5	42	20
Kowalski3 [92]	2001	Germany	100	81	54	52	48
Franceschi [93]	2013	Italy	54	23	44 ± 17	40	14
Tsai [94]	2000	Taiwan	165	114	65.5 ± 8.6	113	52
Bonaventura[95]	2007	Italy	58	34	62.8 ± 9.6	NR	NR
Gunn [96]	2000	England	342	206	65.1 ± 11.9	229	113
Jin [97]	2007	Korea	175	71	62.6 ± 8.6	111	64
Assadi [98]	2009	Iran	30	15	53.20 ± 6.16	12	18
Azarkar [99]	2011	Iran	73	42	59.8 ± 11.5	53	20
Khurshid [100]	1998	USA	119	55	NR	NR	NR
Koenig [101]	1999	Germany	312	126	57.7 ± 7.4	267	45
Darvishi [102]	2016	Iran	84	51	63.12 ± 13.70	41	NR
Markus [103]	1998	England	238	140	65.9	41	43
Regnstrom [104]	1998	Sweden	92	39	40.9	92	0
Warme1 [105]	2023	Sweden	198	39	60	56	142
Warme2 [106]	2020	Sweden	289	57	67	222	67
Alfy [107]	2023	Egypt	100	72	58 ± 12	66	34
Azeem [108]	2022	Egypt	100	60	NR	56	44

NR: Not reported

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ISSN: 1476-0711

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