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Table 1 Characteristics of the 12 KPC-producing Klebsiella pneumoniae strains resistant to Imipenem/cilastatin/relebactam

From: Activity of imipenem/relebactam against KPC-producing Klebsiella pneumoniae and the possible role of Ompk36 mutation in determining resistance: an Italian retrospective analysis

ID

Sequence type (ST)

MIC value for specific antibiotics (S/I/R)

 

IMI/REL

(0.06/4–8/4)

IMI

(1–8)

MEM

(0.12-16)

MVB

(0.06/8–16/8)

C/T

(0.25/4–8/4)

CZA

(0.25/4–16/4)

Carbapenem resistance determinants

Beta-lactams resistant determinants

I091

512

4

> 8

> 16

8

> 8

16

blaKPC−3

blaSHV−11; blaTEM−1;blaOXA−1

G007

307

4

> 8

> 16

2

> 8

8

blaKPC−3

blaSHV−28; blaTEM−1;blaOXA−1

G003

307

4

> 8

> 16

4

> 8

4

blaKPC−3

blaTEM;blaOXA−1

E195

258

4

> 8

> 16

2

> 8

1

blaKPC−2

blaSHV−12

H117

307

4

> 8

> 16

4

> 8

2

blaKPC−2

blaSHV−28;blaOXA−1

A157/2

307

4

> 8

> 16

2

> 8

2

blaKPC−2

blaSHV−28;blaOXA−1

G019

307

4

> 8

> 16

1

> 8

2

blaKPC−3

blaSHV−28; blaTEM−1;blaOXA−1

G021

307

4

> 8

> 16

1

> 8

4

blaKPC−3

blaSHV−28; blaTEM−1;blaOXA−1

G025

258

4

> 8

> 16

4

> 8

2

blaKPC−2

blaSHV−12

C053

258

4

> 8

> 16

4

> 8

2

blaKPC−2

blaSHV−12

B040

307

4

> 8

> 16

2

> 8

2

blaKPC−2

blaSHV−28; blaTEM−1;

blaOXA−1

B100

307

8

> 8

> 16

4

> 8

4

blaKPC−3

blaSHV−28; blaTEM−1;blaOXA

  1. MIC: minimum inhibitory concentration, S: susceptibile, I: increased exposure; R: resistant; IMI/REL: imipenem/cilastatin/relebactam; IMI: imipenem; MEM: meropenem; MVB: meropenem/vaborbactam; C/T: ceftolozane/tazobactam; CZA: ceftazidime/avibactam. Resistance determinants are reported according to the NCBI AMRFinderPlus categorization at the time of analysis. No mutations in OmpK36 were identified. Complete analysis of resistance, virulome and identified plasmids is reported in the Supplementary materials