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Table 2 Protein mutations identified in the strains resistant to to Imipenem/cilastatin/relebactam. Correlation analysis with resistance was performed with all the Ompk36 mutations identified in all the Kp-KPC dataset (603 samples)

From: Activity of imipenem/relebactam against KPC-producing Klebsiella pneumoniae and the possible role of Ompk36 mutation in determining resistance: an Italian retrospective analysis

Protein

Mutation

p value

Ompk36

p.Asp357fs

0,008372

Ompk36

p.Asp135_Thr136insGlyAsp

0,071530

Ompk36

p.Tyr201fs

0,457700

Ompk36

p.Trp125*

0,906200

Ompk36

p.Ala183_Leu184delinsThr

1

Ompk36

p.Asn221His

1

Ompk36

p.AspAsnSer344GluAsnAsp

1

Ompk36

p.HisAsn349ArgArg

1

Ompk36

p.Ile315Leu

1

Ompk36

p.Leu307Ile

1

Ompk36

p.Thr192Gly

1

Ompk36

p.Tyr201Phe

1

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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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