Table 4 Characteristics of disseminated invasive aspergillosis
Underlying disease | Reason for admission at IFI diagnosis | IFI site of involvement | Aspergillus species | Prior AF (breakthrough IFI) | Concomitant coinfection | Outcome | |
|---|---|---|---|---|---|---|---|
Patient 1 | Bilateral lung transplant. Second bilateral lung transplant one year later | Surgical wound dehiscence and infection | Surgical wound, eye, sternum and mediastinum | A. terreus | Nebulized AmphoB | No | Dead |
Patient 2 | Acute respiratory distress syndrome secondary to SARS-Cov2 infection | SARS-CoV2 | Lung and eye | A. fumigatus | No | Several infections during admission (R. ornithinolytica nosocomial pneumonia, E. faecalis bacteremia. Empyema due to E. faecium. Cystitis due to P. aeruginosa | Dead |
Patient 3 | Cardiogenic shock due to acute myocardial infarction, need for ventricular assistance | Cardiogenic shock due to acute myocardial infarction, ventricular assistance | Lung, mediastinum and surgical wound infection and ventricular assistance infection | A. fumigatus | No | No | Transfer to referral hospital |
Patient 4 | Lung transplant | Acute rejection | Lung, brain, skin and pulmonary vein | A. fumigatus | Nebulized AmphoB | Pseudomonas aeruginosa pneumonia | Dead |
Patient 5 | Kidney transplant | Solid mass in left leg | Lung and muscle | A. fumigatus | No | No | Alive, lost graft, suppressive chronic AF |
Patient 6 | Acute promyelocytic leukemia | Induction chemotherapy | Lung, brain and spine | A. terreus | Posaconazole | K. pneumoniae pneumonia | Alive without AF |